Brevetti Angela, specialist in BFS technology, offers solutions for filling parenterals in containers under aseptic conditions. Next, a little about the process itself: How is the production of containers using BFS technology?

1. Extrusion

Extrusion of plastic pellets in the form of a hollow tube of molten plastic, which is called a "parison".

2. Blowing

As the mold closes over the parison, the container is shaped by the pressure difference between the inside and outside of the parison, which can be created either by purging with sterile filtered compressed gas (air, nitrogen, or any other inert gas) or by applying vacuum to the mold cavities .

3. Filling

The filling nozzles enter from the top of the container and inject the product into the formed containers. At this stage, the filling nozzles and container openings are protected by a stream of sterile filtered air to prevent contamination. The performance of the sterile air shower can be constantly monitored using a particle counter.

4. Sealing

Once filled, the top of the hot parison gets pressed between the molds to seal the container tightly.

5. Deflashing

The last step is to remove the flash (excess polymer or waste) or trim and dispense the containers outside the machine.

Please contact us for more information on equipment.